地西泮在口服後，迅速被身體吸收，藥效很快開始，以靜脈注射，藥效更快。地西泮經肝臟代謝，其代謝物經腎臟排泄，只有極少量的地西泮沒有被代謝便排泄。
Intravenous or intramuscular injections in hypotensive people today or those in shock is administered cautiously and important indications are intently monitored.[61]
Diazepam is matter to Timetable IV Handle beneath the Controlled Substances Act of 1970. Abuse and dependence of benzodiazepines are already described. Dependancy-prone individuals (like drug addicts or alcoholics) ought to be less than very careful surveillance when obtaining diazepam or other psychotropic agents due to the predisposition of these individuals to habituation and dependence.
VALTOCO is the one prescription nasal spray made use of to right away address episodes of frequent seizures in Older people and youngsters six many years and older. It’s various from your every day anti-seizure remedies—you employ VALTOCO only when needed.
次にクロロ酢酸クロリドとのショッテン・バウマン反応によりアミノ基をクロロアセチル化する。さらに水酸化ナトリウム存在下で反応させると、オキシム窒素のクロロアセチル基への求核置換が起こり、ベンゾジアゼピン骨格が形成される。なお、スターンバックらはこの化合物の合成法について、同じ文献上でいくつかの別法も報告している。
Overdose of benzodiazepines in combination with other CNS depressants (which includes Liquor) may very well be deadly and will be intently monitored.
“There is one thing empowering about obtaining an instantaneous-use seizure medication that works for you, and I think for me, this was a sign that some thing could be done about epilepsy, that we didn’t have to Permit it rule in excess of our lives any more.”
The success of diazepam in very long-expression use, that is, in excess of 4 months, has not been assessed by systematic scientific research. The medical professional need to periodically reassess the usefulness on the drug for the individual patient.
Diazepam is the most typical benzodiazepine Employed in canine and cats to reduce motor activity and allow the placement of the IV catheter.
Keep an eye on neonates subjected to diazepam throughout pregnancy or labor for signs of sedation and watch neonates subjected to diazepam throughout pregnancy for signs of withdrawal; control these neonates accordingly. Safeguards
N-desmethyldiazepam and temazepam are the two even more metabolized to oxazepam. Temazepam and oxazepam are mostly eradicated by glucuronidation.
How to proceed When you give VALTOCO Should the seizures do not quit or There exists a adjust in respiration, conduct, or situation that concerns you
Withdrawal Reactions Inform clients that the continued usage of diazepam could lead to clinically sizeable physical dependence Which abrupt discontinuation or fast dosage reduction of diazepam might precipitate acute withdrawal reactions, which can be life-threatening. Tell people that occasionally, people getting benzodiazepines have designed a protracted diazepam sverige withdrawal syndrome with withdrawal signs or symptoms lasting weeks to much more than 12 months.
Phenytoin: There have also been reports which the metabolic elimination of phenytoin is diminished by diazepam.